In a stark update on the deteriorating condition of our planet, an international assembly of climate experts has reported that the Earth’s vital signs have declined to levels never before witnessed in human history. This critical state threatens the very fabric of life on our planet.



<h2 class="wp-block-heading" id="h-unprecedented-scientific-consensus">Unprecedented scientific consensus</h2>



Led by William Ripple, a prominent figure from the Oregon State University <a href="https://www.forestry.oregonstate.edu/" target="_blank" rel="noreferrer noopener">College of Forestry</a>, and Christopher Wolf, formerly associated with OSU, a team comprising 12 scientists has delivered a grim prognosis on Earth&#8217;s vital signs in their paper published in <a href="https://academic.oup.com/bioscience/article-lookup/doi/10.1093/biosci/biad080" target="_blank" rel="noreferrer noopener">BioScience</a>. 



Titled &#8220;The 2023 State of the climate report: Entering uncharted territory,&#8221; the study underscores that a staggering 20 out of 35 planetary vital signs used as barometers for climate health have hit record extremes.



<h2 class="wp-block-heading" id="h-world-on-the-brink">World on the brink</h2>



&#8220;Without decisive steps to address the fundamental issue of humanity&#8217;s overconsumption of the Earth&#8217;s resources, we are navigating towards the potential disintegration of natural and socioeconomic systems,&#8221; Wolf stated, painting a picture of a future marred by intolerable heat, food scarcity, and water shortages.



The authors highlight alarming data from 2023, pointing out that numerous records related to climate and Earth&#8217;s vital signs have been shattered &#8220;by enormous margins.&#8221; This includes unprecedented ocean temperatures, drastic reductions in sea ice, and an extraordinary Canadian wildfire season contributing to record levels of carbon dioxide emissions.



<h2 class="wp-block-heading" id="h-echoes-of-past-warnings">Echoes of past warnings</h2>



This report is not the first of its kind. It follows a significant &#8220;<a href="https://www.earth.com/news/climate-change-has-pushed-earth-to-code-red/" target="_blank" rel="noreferrer noopener">World Scientists’ Warning of a Climate Emergency</a>&#8221; published four years ago, where Ripple, alongside other collaborators, received support from over 15,000 scientists from 161 countries. 



Despite these earlier calls to action, little progress has been made, with Ripple emphasizing, &#8220;Life on our planet is unmistakably under assault.&#8221;



<h2 class="wp-block-heading" id="h-alarming-climate-health-statistics">Alarming climate health statistics</h2>



The report lays bare several shocking statistics that outline why Earth&#8217;s vital signs are at an all-time low.



<ul class="wp-block-list">
<li><a href="https://www.earth.com/news/un-chief-fossil-fuel-era-must-end-for-humanitys-survival/" target="_blank" rel="noreferrer noopener">Fossil fuel</a> subsidies saw a staggering increase from $531 billion to over $1 trillion between 2021 and 2022, incentivizing harmful emissions. </li>



<li><a href="https://www.earth.com/news/wildfires-amplify-risks-for-socially-vulnerable-populations-in-western-states/" target="_blank" rel="noreferrer noopener">Wildfires</a> in Canada alone have already contributed more than 1 gigaton of carbon dioxide to the atmosphere in 2023, surpassing the nation&#8217;s total greenhouse gas emissions the previous year. </li>



<li>A concerning trend in global temperature rise, with 38 days already recorded where temperatures were more than <a href="https://www.earth.com/news/limiting-global-warming-to-1-5-degrees-celsius-would-save-billions-of-lives/" target="_blank" rel="noreferrer noopener">1.5 degrees Celsius</a> above pre-industrial levels. </li>



<li>July experienced the <a href="https://www.earth.com/news/july-was-earths-hottest-month-in-120000-years/" target="_blank" rel="noreferrer noopener">highest average</a> Earth surface temperature on record, likely the most extreme in the last 100,000 years.</li>
</ul>



Wolf expressed deep concern, stating, &#8220;As scientists, the sudden escalation in the frequency and intensity of climate-related disasters is deeply unsettling.&#8221;



The study cautions that these disasters&#8217; frequency and intensity might even be accelerating faster than temperature rises. The paper forecasts a dire future, where 3 to 6 billion people will find themselves in uninhabitable conditions by the end of this century.



<h2 class="wp-block-heading" id="h-earth-s-vital-signs-need-transformative-policies">Earth&#8217;s vital signs need transformative policies</h2>



The scientific community is advocating for policies that address &#8220;ecological overshoot,&#8221; a scenario where humanity&#8217;s demands exceed the Earth&#8217;s capacity, resulting in numerous environmental crises, including a decline in biodiversity.



They argue that solutions focusing solely on carbon or climate will fall short of repairing Earth&#8217;s vital signs unless the overarching pressures on global systems are alleviated. As Ripple puts it, the scientific community has a &#8220;moral duty&#8221; to guide humanity away from potential existential threats and lead action-driven dialogues.



<h2 class="wp-block-heading" id="h-steering-towards-a-just-sustainable-future">Steering towards a just, sustainable future</h2>



The paper calls for a comprehensive overhaul of global economic practices. The authors of the study urge a transition that foregrounds human well-being, curtails excessive consumption, and drastically reduces affluent populations&#8217; emissions.



Key policy recommendations to reverse the decline of Earth&#8217;s vital signs include:



<ul class="wp-block-list">
<li>Eliminating fossil fuel subsidies. </li>



<li>Encouraging shifts towards plant-based diets. </li>



<li>Amplifying efforts to protect global forest areas. </li>



<li>Establishing international treaties focused on eliminating coal and preventing new fossil fuel exploration.</li>
</ul>



The authors underscore the necessity for equity and social justice in all climate-related decisions. They clearly recognize the disproportionate impact of climate calamities on the world&#8217;s most impoverished populations, who have the smallest carbon footprints.



In a world where climate-related disasters are becoming the norm rather than the exception, this clarion call from the scientific community is more urgent than ever. It implores global leaders, decision-makers, and individuals alike to embark on a more sustainable path, with the understanding that the very future of life on Earth hinges on the actions humanity takes now.



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Life under siege: Earth’s vital signs reach an all-time low

Apple,Cider,Vinegar,On,A,Metal,Spoon,Above,A,Glass

Every year, tens of millions of people around the world wrestle with bad moods and various levels of depression. Prescription drugs help many sufferers, yet side effects, cost, and uneven results often leave patients and clinicians on the lookout for other solutions. 



Then one day, as with all urban myths, one person told another who told another about a home remedy that never seems to fail. If you want to <a href="https://www.earth.com/news/is-depression-contagious-couples-may-share-it-through-kissing/">beat depression</a>, taking just one spoonful of vinegar every day will wash those blue away. 



When you stop and think about it for a minute, diet does seem like an obvious place to turn for cures to most any ailment. After all, the body and mind operate on what we feed them.



Could the same sour splash that wakes up a salad also nudge a weary mind toward optimism? 



Two small <a href="https://clinicaltrials.gov/study/NCT04706806" target="_blank" rel="noreferrer noopener">clinical trials suggests</a> that the idea of treating depression with a spoonful of vinegar is definitely worth more attention from medical professionals and the public.



<h2 class="wp-block-heading" id="h-studying-vinegars-impact-on-depression">Studying vinegars impact on depression</h2>



Fermented vinegars have had a place in folk remedies for centuries, prized for their ability to tame <a href="https://www.earth.com/news/drinking-this-amount-of-water-per-day-helps-control-blood-sugar-levels-in-people-with-diabetes/" target="_blank" rel="noreferrer noopener">blood sugar spikes</a> and add zest without salt or fat. 



Scientific studies over the past decade have confirmed some metabolic perks, yet mental health has been missing from the conversation. 



That gap inspired a team of nutrition researchers to see whether swallowing some vinegar on a regular schedule could ease depression by influencing mood-related chemistry as well as subjective feelings.



Led by <a href="https://www.asu.edu/" target="_blank" rel="noreferrer noopener">Arizona State University</a> dietitian Haley Barrong, the investigators recruited 28 overweight but otherwise healthy adults and randomly assigned them to one of two groups. 



Half drank two tablespoons of red wine vinegar diluted in water twice a day, while the rest swallowed a capsule containing only a trace of vinegar.



<h2 class="wp-block-heading" id="h-what-the-team-learned">What the team learned</h2>



Over four weeks, all participants completed the Center for Epidemiological Studies Depression questionnaire (<a href="https://nida.nih.gov/sites/default/files/Mental_HealthV.pdf" target="_blank" rel="noreferrer noopener">CES-D</a>) and the Patient Health Questionnaire-9 (<a href="https://med.stanford.edu/fastlab/research/imapp/msrs/_jcr_content/main/accordion/accordion_content3/download_256324296/file.res/PHQ9%20id%20date%2008.03.pdf" target="_blank" rel="noreferrer noopener">PHQ-9</a>).



Scores on the CES-D hardly budged, yet the PHQ-9 told another story. In the vinegar group, reported depressive symptoms fell by an average of 42 percent, compared with an 18 percent dip in the pill group. 



After reviewing the data, the authors wrote, “This data provides additional support that daily vinegar ingestion over four weeks can improve self-reported depression symptomology in generally healthy adults and that alterations in [<a href="https://www.earth.com/news/vitamin-b-paradox-supplement-linked-to-heart-disease-risk/" target="_blank" rel="noreferrer noopener">vitamin B3</a>] metabolism may factor into this improvement.”



<h2 class="wp-block-heading" id="h-vinegar-depression-and-blood">Vinegar, depression, and blood</h2>



The team also collected blood samples to watch biochemical pathways at work. The most striking change was an 86 percent surge in nicotinamide, a form of vitamin B3 that feeds into the NAD⁺ salvage pathway responsible for cellular energy recycling. 



Higher nicotinamide aligns with lower inflammation, a relationship that has caught psychiatric interest before. 



Two metabolites - <a href="https://www.earth.com/news/eating-less-of-this-amino-acid-isoleucine-boosts-lifespan-in-mice-an-average-of-33-percent/">isoleucine</a>, a branched-chain amino acid, and <a href="https://pubchem.ncbi.nlm.nih.gov/compound/Isobutyric-acid" target="_blank" rel="noreferrer noopener">isobutyric acid</a> - shifted as well, hinting that vinegar tweaks broader metabolic networks tied to mood regulation.



“Depressive disorders are the most prevalent mental health conditions in the world,” write the researchers. 



“The commonly prescribed antidepressant medications can have serious side effects, and their efficacy varies widely. Thus, simple, effective adjunct therapies are needed.”



<h2 class="wp-block-heading" id="h-how-vinegar-might-lift-mood">How vinegar might lift mood</h2>



Several mechanisms could explain the modest improvements. Acetic acid, the defining ingredient in vinegar, activates AMP-activated <a href="https://www.earth.com/news/studies-learn-the-exact-amount-of-time-you-should-spend-training-to-build-muscle/">protein kinase</a>, an energy sensor linked to <a href="https://pubmed.ncbi.nlm.nih.gov/25308486/" target="_blank" rel="noreferrer noopener">NAD⁺ production</a>. 



More NAD⁺ means brain cells repair DNA damage more effectively and maintain healthy mitochondria. 



Another possibility involves the gut. <a href="https://www.earth.com/news/scientifically-proven-tips-for-better-kombucha-brewing/">Acetic acid</a> can encourage growth of friendly bacteria that generate neurotransmitter precursors, forging a gut-brain feedback loop many neuroscientists now consider crucial to emotional balance.



Lab work in mice has already shown that boosting NAD⁺ protects neurons from stress hormones, while human studies connect higher dietary vitamin B3 with lower depression risk. 



The present human trial knits those ideas together: swallow vinegar, raise nicotinamide levels, and perhaps give the brain an energetic lift.



<h2 class="wp-block-heading" id="h-depression-vinegar-and-health">Depression, vinegar, and health</h2>



None of this turns vinegar into a standalone treatment. The experiment lasted only a month, involved people with mild symptoms, and lost some statistical punch after adjusting for baseline scores. 



Still, swallowing a familiar pantry staple twice a day costs pennies and carries few risks for most adults. 



“Future research examining the effects of vinegar administration in clinically depressed or at-risk populations, and those on antidepressant medications, is warranted," the authors concluded.



“A focus on mechanisms and large patient samples will strengthen the science and provide the evidence to more firmly demonstrate vinegar's role in health promotion.” 



Until those larger trials wrap up, dietitians may simply remind clients that incorporating two tablespoons of red wine or apple cider vinegar into meals is safe for most, provided they dilute it and protect their teeth by rinsing with water.



<h2 class="wp-block-heading" id="h-future-studies-on-depression-and-vinegar">Future studies on depression and vinegar</h2>



People interested in trying the routine might start by whisking vinegar into dressings or stirring it into a tall glass of water before lunch and dinner. 



Anyone with <a href="https://www.earth.com/news/junk-food-diet-triggers-lasting-changes-in-the-brain/">acid reflux</a>, kidney issues, or current prescriptions should check with a clinician first. 



<a href="https://www.earth.com/news/how-nature-heals-outdoor-activities-greatly-improve-mental-health/">Mental health</a> professionals could eventually blend such low-cost dietary tweaks with therapy and medication, tailoring care to each person’s biology and preferences.



The notion that mood can shift alongside something as ordinary as a mealtime condiment highlights how tightly body and mind intertwine.



Vinegar will never replace professional treatment, yet its potential to turn that frown upside down - especially for those reluctant to take pharmaceuticals - deserves the careful follow-up studies that this research team calls for. 



The full study was published in the journal <a href="https://www.mdpi.com/2072-6643/16/14/2305" target="_blank" rel="noreferrer noopener">Nutrients</a>.



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Study identifies a much easier and cheaper way to treat depression than with prescription drugs

Every year, tens of millions of people around the world...

Archaeologists in central France have uncovered two swords, buried for roughly 2,300 years, that still glint with inlaid glass and copper. The <a href="https://www.inrap.fr/la-necropole-celtique-des-ancises-creuzier-le-neuf-allier-19987" target="_blank" rel="noreferrer noopener">finds</a> sit among more than one hundred grave pits on a hill overlooking the small town of Creuzier‑le‑Neuf.



The site’s burial ground dates to the early fourth century B.C. and covers nearly 7,000 square feet, a scale rarely matched for <a href="https://www.worldhistory.org/La_Tene_Culture/" target="_blank" rel="noreferrer noopener">La Tène‑period France</a>. 



Benjamin Oury of the National Institute for Preventive Archaeological Research (<a href="https://www.inrap.fr/en" target="_blank" rel="noreferrer noopener">INRAP</a>), who led the excavation, says every object pulled from the soil helps reconstruct Celtic life at a political crossroads.



<h2 class="wp-block-heading" id="h-celtic-swords-and-burial-sites">Celtic swords and burial sites</h2>



Soil acidity has stripped the skeletons away, yet iron‑oxide cocoons preserved many <a href="https://www.earth.com/news/metal-detectors-find-a-2500-year-old-dagger-that-opens-a-new-window-on-history/">metal</a> offerings in place. 



Almost half of the graves still contained jewelry, weaponry, or costume fittings that slid free once conservators separated the rust from the soil matrix.



The enclosure itself is quadrangular, edged by a ditch wide enough to signal communal effort rather than family memory. 



Orientation north to south keeps the rows tidy, hinting at coordinated <a href="https://www.earth.com/news/archaeologists-discover-141-ancient-gold-coins-some-from-a-little-known-roman-emperor/">funeral rites</a> rather than hurried internment.



Only one tomb held a cremation, and it came with a painted clay vase whose red spirals echo Mediterranean pottery fashions. 



Work at other <a href="https://www.history.com/articles/iron-age" target="_blank" rel="noreferrer noopener">Second Iron Age</a> cemeteries shows such decorated urns riding trade routes that reached the Rhône Valley and beyond.



<h2 class="wp-block-heading" id="h-metalwork-that-defies-time">Metalwork that defies time</h2>



Eighteen fibulas, some iron and others copper‑alloy, surfaced in fragile bundles but stabilized cleanly in <a href="https://www.viennalab.com/" target="_blank" rel="noreferrer noopener">Vienna’s CREAM laboratory</a>. 



One brooch carries a silver‑leafed gem while another shows <a href="https://www.numisantica.com/en/ancient-beads-jewellery/ancient-beads/iron-age-celtic-glass-stratified-eye-bead/a-19705-10000099" target="_blank" rel="noreferrer noopener">ocelli</a>, or eye‑shaped bosses that Celtic artisans favored during the fifth and fourth centuries B.C..



Bracelets came up in pairs for several burials, their terminals socketed so neatly that the clasp disappears when closed. 



A matched set bears concentric rings so deeply punched that fresh hammer marks still catch light under magnification.



Copper spheres sit atop some clasps like berries on a stem, a motif echoed on harness fittings found in Champagne burials two hundred miles away. 



Shared decorative grammar points to workshops trading not only goods but patterns across tribal frontiers.



<h2 class="wp-block-heading" id="h-two-celtic-swords-two-stories">Two Celtic swords, two stories</h2>



“The longer sword has all the characteristics of a functional weapon,” said <a href="https://www.researchgate.net/profile/Vincent-Georges" target="_blank" rel="noreferrer noopener">Vincent Georges</a>, archaeologist at INRAP. One Celtic sword stretches long enough to ride at a horseman’s waist, its sheath edged by cabochons of glass paste. 



Textile fragments clung to the back plate of the scabbard, probably the deceased’s cloak, and X‑ray stripes show the belt rings had never been pried away. 



Even oxidation respected the original geometry, letting conservators measure the blade within two millimeters of its working length.



The second weapon is shorter, leaf‑shaped, and clearly <a href="https://www.earth.com/news/mystery-of-pirunkirkko-the-cave-that-whispers-secrets-of-the-past/">ceremonial</a>, its copper hilt tipped with small bronze balls called antennae. 



Georges added that the piece is “more or less contemporary with the Celtic incursions in northern Italy and the sacking of Rome in 387 B.C.”



<h2 class="wp-block-heading" id="h-tracing-the-swastika-s-earlier-meaning">Tracing the swastika’s earlier meaning</h2>



Two gems on the ceremonial sheath carry neat engravings of the <a href="https://landiscenter.lafayette.edu/2017/02/06/swastika-the-symbol-of-good-fortune-or-that-of-the-nazi/" target="_blank" rel="noreferrer noopener">swastika</a>, a cross with right‑angled arms that ancient cultures read as luck or cosmic motion. 



<a href="https://www.lboissoneault.com/about" target="_blank" rel="noreferrer noopener">Historian Lorraine Boissoneault</a> documents the emblem on artifacts from India to the Mississippi Valley long before its Nazi appropriation.



Classical collections show the motif spreading across the Mediterranean by the sixth century B.C., then drifting north with Celtic migration. 



Its presence here, tucked beside a crescent and full circle inlaid on the blade itself, suggests celestial or solar connotations rather than any martial boast.



The <a href="https://arkeonews.net/exceptional-iron-age-artifacts-discovered-at-celtic-necropolis-in-central-france/" target="_blank" rel="noreferrer noopener">Creuzier‑le‑Neuf sword</a> adds the earliest Western European example carved into gemstone, a technique more at home in <a href="https://quod.lib.umich.edu/b/bulletinfront/0054307.0015.104/--hellenistic-archives-from-tel-kedesh-israel-and-seleucia?rgn=main;view=fulltext" target="_blank" rel="noreferrer noopener">Hellenistic seal rings</a>. Such hybrid artistry underscores how porous cultural borders were, even during localized feuds.



<h2 class="wp-block-heading" id="h-on-the-frontier-of-celtic-power">On the frontier of Celtic power</h2>



Creuzier‑le‑Neuf lay where the Arverni, Aedui, and Bituriges territories overlapped, a liminal patch that prospered on exchange and occasional tension. 



Trade beads from Mediterranean workshops enter local rivers just as Arverni bronze flows south into alpine passes.



History remembers the wider Celtic world for routing Roman troops at the Battle of Allia on July 18, 387 B.C., a clash that left Rome paying gold for its freedom. 



The ornamental Celtic sword’s dating to that generation hints that prestige weapons doubled as status badges while real steel rode to war.



All three tribes maintained fortified oppida within a day’s march, yet they buried their dead together here, suggesting overlapping kin networks or shared sacred ground. 



<a href="https://www.earth.com/news/bronze-age-people-abandoned-meat-for-millet-3500-years-ago/">Isotope work</a> planned for the sheath alloys may reveal whether ores came from <a href="https://www.mindat.org/loc-332900.html" target="_blank" rel="noreferrer noopener">Massif Central mines</a> or more distant sources tied to intertribal alliances.



Yet no slash notches scar the blade edges, confirming Georges’ view that the shorter sword lived mainly as insignia of rank. Function bowed to symbolism, and symbolism borrowed from everywhere.



<h2 class="wp-block-heading" id="h-what-the-artifacts-tell-us">What the artifacts tell us</h2>



Without bones to speak for them, the objects narrate diet, trade, and hierarchy. Cabochons likely held imported glass, bracelets mimic <a href="https://www.world-archaeology.com/features/la-tene/" target="_blank" rel="noreferrer noopener">La Tène type‑A catalogs</a>, and the swords compress the story of shifting alliances into metal and stone.



Oury calls the site “a classroom for understanding how identity was displayed in death,” and future residue studies on corrosion layers may pinpoint burial textiles or pigments. 



Conservation continues, but plans for a regional museum display are already under discussion.



Each cleaned item reminds visitors that symbols travel farther than armies. A sign once bent toward thunder gods now rests on a sword that never drew blood, carried by someone who wanted to be remembered, and was.



Photo: <a href="https://www.inrap.fr/sites/inrap.fr/files/thumbnails/image/f250211_inrapmocreuzier_143.jpg" target="_blank" rel="noreferrer noopener">Flore Giraud</a>, Inrap.



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Archaeologists find 2,300-year-old swords adorned with gems and ancient symbols

Archaeologists in central France have uncovered two swords, buried for...

Cell biology is a world of constant motion and hidden structures. Much of what we know about cells comes from decades of research using microscopes, stains, and models. Yet, even in this well-charted territory, surprises still emerge - enter the "hemifusome."



This previously unknown organelle may help explain how cells sort, recycle, and discard their internal cargo. This function is vital to life and is often disrupted in instances of genetic disease.



The discovery of this organelle, which was made by scientists at the <a href="https://www.virginia.edu" target="_blank" rel="noreferrer noopener">University of Virginia</a> and the National Institutes of Health (<a href="https://www.nih.gov" target="_blank" rel="noreferrer noopener">NIH</a>), offers a new lens through which to study the inner workings of the cell. 



It also presents a possible turning point for understanding diseases where cellular housekeeping breaks down. Using cutting-edge imaging tools, researchers have caught this <a href="https://www.earth.com/news/cambrian-explosion-fossils-push-back-the-rise-of-complex-life/">organelle</a> in action and outlined its potential impact on health and medicine.



<h2 class="wp-block-heading" id="h-introducing-the-hemifusome">Introducing the hemifusome</h2>



The hemifusome is not a static component but a temporary structure that appears and disappears depending on the cell’s needs. 



It consists of two vesicles joined together by a partial membrane connection called a hemifusion diaphragm.



In this configuration, the vesicles do not fully merge but maintain a shared boundary that allows them to interact without blending entirely.



"This is like discovering a new recycling center inside the cell," said researcher Seham Ebrahim, Ph.D., of UVA's Department of Molecular Physiology and Biological Physics. 



"We think the hemifusome helps manage how <a href="https://www.earth.com/news/third-state-of-existence-beyond-life-and-death-confirmed-by-scientists/">cells</a> package and process material, and when this goes wrong, it may contribute to diseases that affect many systems in the body."



These hemifused vesicles appear in two configurations. In the direct form, a smaller vesicle is attached to the outer side of a larger one, whereas in the flipped version, the smaller vesicle is embedded on the inner, or luminal, side. 



In both cases, a dense particle called a proteolipid nanodroplet anchors the structure at the junction, possibly guiding its formation and stability.



<h2 class="wp-block-heading" id="h-how-the-hemifusome-appears">How the hemifusome appears</h2>



To study hemifusomes, researchers turned to cryo-electron tomography (cryo-ET). This imaging method freezes cells rapidly, preserving them close to their natural state. 



Unlike traditional <a href="https://www.earth.com/news/watching-electrons-move-1-quintillionth-of-second-attoseconds-attomicroscopy/">electron microscopy</a>, which can distort or destroy delicate structures, cryo-ET allows scientists to see cellular architecture as it truly exists.



By scanning the outer edges of four mammalian cell types, COS-7, HeLa, RAT-1, and NIH/3T3, the team identified hundreds of hemifusomes. These organelles made up nearly 10 percent of all membrane-bound vesicles in those regions. 



<figure class="wp-block-image aligncenter size-full"><a href="https://www.earth.com/wp-content/uploads/2025/07/hemifused-vesicles_cryo-electron-tomography_Nature-Communications_1m.jpg"><img src="https://www.earth.com/wp-content/uploads/2025/07/hemifused-vesicles_cryo-electron-tomography_Nature-Communications_1s.webp" alt="Cryo-electron tomography observation of hemifused vesicles at the leading edge of cultured cells. Credit: Nature Communications (2025)" class="wp-image-1976051"/></a><figcaption class="wp-element-caption">Cryo-electron tomography observation of hemifused vesicles at the leading edge of cultured cells. Click image to enlarge. Credit: Nature Communications (2025)</figcaption></figure>



Their consistency across <a href="https://www.earth.com/news/why-millions-of-fungal-species-still-remain-unknown/">cell</a> types suggests they are not rare anomalies but common cellular components.



"You can think of vesicles like little delivery trucks inside the cell," said Ebrahim, of UVA's Center for Membrane and Cell Physiology. "The hemifusome is like a loading dock where they connect and transfer cargo. It's a step in the process we didn't know existed."



<h2 class="wp-block-heading" id="h-what-makes-the-hemifusome-unique">What makes the hemifusome unique</h2>



Hemifusomes stand out not just for their shape, but for what’s inside them. The larger vesicle usually contains granular material, similar to what is seen in <a href="https://www.earth.com/news/mitochondria-cells-batteries-leaking-causes-inflammation-diseases/">endosomes</a> and ribosome-associated vesicles.



But the smaller vesicle shows a smooth, translucent interior. This likely reflects a protein-free or dilute aqueous solution, setting it apart from other vesicles in the cell.



The hemifusion diaphragm itself is unusually large, about 160 nanometers in diameter, far bigger than the 10 nanometer diaphragms seen in standard vesicle fusion <a href="https://www.earth.com/news/gold-eating-fungus-discovery-could-revolutionize-the-search-for-metals-and-minerals-on-earth-asteroids-and-other-planets/">events</a>. These extended diaphragms appear stable, not fleeting, suggesting they may be designed to last. 



In some cases, the diaphragm grows large enough to engulf the entire smaller vesicle into the larger one’s bilayer, creating a lens-like shape known in simulations as dead-end hemifusion. Seeing this in actual cells challenges the idea that such formations are purely theoretical.



<h2 class="wp-block-heading" id="h-anchors-and-architects-of-the-organelle">Anchors and architects of the organelle</h2>



One consistent feature at the heart of hemifusomes is the dense proteolipid nanodroplet, or PND. About 42 nanometers in diameter, these droplets are lodged at the rim of the hemifusion site. 



Their content, lipids and proteins, suggests they may help build or stabilize the hemifused structure.



These PNDs have never been observed in such a role before. Some appear free in the cytoplasm, others are embedded in membranes. Researchers propose that PNDs may serve as scaffolds for assembling new vesicles. 



As the PND integrates into a membrane, it may kickstart the formation of the smaller vesicle seen in hemifusomes.



This process, described as <a href="https://www.sciencedirect.com/topics/neuroscience/vasculogenesis" target="_blank" rel="noreferrer noopener">de novo vesiculogenesis</a>, stands apart from classical vesicle fusion. The presence of a unique, translucent vesicle and the absence of known docking steps indicate the hemifusome may follow its own assembly path.



<h2 class="wp-block-heading" id="h-are-hemifusomes-related-to-endosomes">Are hemifusomes related to endosomes?</h2>



Given their location and size, hemifusomes resemble some endosomal structures. To investigate this further, the researchers traced the journey of gold nanoparticles, common markers used to map endocytic activity. 



The particles entered known endosomes and <a href="https://www.earth.com/news/tricking-cells-into-thinking-they-ate-less-food-can-slow-aging-process/">lysosomes</a> but never appeared inside hemifusomes. This absence suggests that hemifusomes do not belong to the classical endocytic pathway.



Instead, they may represent a separate system operating independently of the cargo sorting carried out by proteins like ESCRT. This distinction may have wide implications for how we understand vesicle traffic inside cells.



<h2 class="wp-block-heading" id="h-multivesicular-bodies-and-disease">Multivesicular bodies and disease</h2>



Some hemifusomes evolve into more complex structures. The study observed compound hemifusomes that contained multiple vesicles, all partially fused. 



These could be early versions of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/multivesicular-body" target="_blank" rel="noreferrer noopener">multivesicular bodies</a> (MVBs), which cells use to break down and recycle internal material.



In the canonical model, ESCRT proteins form inward buds that eventually pinch off inside a larger vesicle. But in hemifusomes, vesicles grow inward through hemifusion and expand with the help of PNDs. 



This alternative route might explain how MVBs form in ways not covered by traditional theories.



One such condition affected by these pathways is Hermansky-Pudlak syndrome. It is a genetic disorder marked by defects in pigmentation, lung function, vision, and bleeding. <a href="https://www.earth.com/news/damaged-mitochondria-recycled/">Cellular recycling</a> issues are central to the disease.



Understanding the hemifusome may help explain these disruptions and lead to future treatments.



<h2 class="wp-block-heading" id="h-a-new-model-for-vesicle-formation">A new model for vesicle formation</h2>



The study proposes a full model where PNDs trigger the formation of translucent vesicles that partially fuse with larger ones, forming hemifusomes. 



These structures may then bud inward, transforming into flipped hemifusomes. Over time, they could scission off as free vesicles inside MVBs.



In contrast to the ESCRT system, which requires tight protein coordination, this mechanism relies on structural and biophysical cues. 



It also sidesteps the need for large lipid donations from other organelles, solving a long-standing puzzle in vesicle formation research.



"This is just the beginning," Ebrahim said. "Now that we know hemifusomes exist, we can start asking how they behave in healthy cells and what happens when things go wrong. That could lead us to new strategies for treating complex genetic diseases."



<h2 class="wp-block-heading" id="h-what-comes-next">What comes next</h2>



The implications of this discovery stretch far beyond cell biology. By offering a new pathway for how cells build and manage internal compartments, the hemifusome challenges decades of assumptions. 



It also invites new thinking about disease, especially conditions where cells fail to manage their waste.



Future research will focus on identifying what proteins guide hemifusome formation and how PNDs are created. 



Scientists also want to know if these structures exist in other parts of the cell, not just at the periphery. Advanced imaging tools and genetic models will be key to answering these questions.



In a field where many believed the major organelles were already mapped, the hemifusome serves as a reminder. The cell still holds secrets. And some of them could lead to cures.



The study is published in the journal <a href="https://www.nature.com/articles/s41467-025-59887-9" target="_blank" rel="noreferrer noopener">Nature Communications</a>.



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New structure found inside human cells could radically change health and medicine

Cell biology is a world of constant motion and hidden...

Many people still believe that building muscle means living at the gym and constantly training. Fresh evidence shows that it's not quite that time-consuming.



The evidence comes from an eight‑week trial led by exercise scientist <a href="https://www.lehman.edu/academics/health-human-services-nursing/exercise-sciences-recreation/bradley-schoenfeld/" target="_blank" rel="noreferrer noopener">Brad Schoenfeld</a> of <a href="https://www.lehman.edu/" target="_blank" rel="noreferrer noopener">Lehman College</a>, whose team asked healthy lifters to finish one demanding set of nine classic moves twice a week.



<h2 class="wp-block-heading" id="h-muscle-training-minutes">Muscle training minutes</h2>



A muscle grows when stress outweighs its usual workload, a chain that starts with mechanical tension and metabolic stress, then ends with more contractile proteins. Short sessions that reach high effort check all those boxes, even if the calendar space is small.



Public health agencies already <a href="https://www.cdc.gov/physical-activity-basics/guidelines/adults.html" target="_blank" rel="noreferrer noopener">tell</a> adults to hit two days of resistance work, yet fewer than one in four Americans manage the target. Shaving sessions to thirty minutes lowers the barrier without watering down the stimulus.



A 2022 <a href="https://pubmed.ncbi.nlm.nih.gov/30153194/" target="_blank" rel="noreferrer noopener">meta‑analysis</a> on trained men and women reported that just three weekly thirteen‑minute bouts raised strength almost as much as forty‑minute routines when total effort matched. In other words, quality can beat quantity if each rep counts.



Schoenfeld’s experiment now confirms the principle over a longer eight‑week window and in a mixed‑sex sample. That widens the practical appeal beyond seasoned bodybuilders.



Cells respond to energy shortages created by <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10801605/" target="_blank" rel="noreferrer noopener">intense contractions</a> by releasing adenosine monophosphate–activated protein kinase, a switch that boosts glucose uptake and supports muscle repair. Hitting that threshold does not require marathon workouts.



<h2 class="wp-block-heading" id="h-what-the-study-measured">What the study measured</h2>



Forty‑two volunteers rotated through a lat pull‑down, seated row, shoulder press, chest press, triceps push‑down, supinated curl, Smith‑machine squat, leg press, and leg extension. Each visit lasted thirty minutes including brief warm‑ups and one‑minute rest periods.



Researchers used ultrasound to gauge thickness in the biceps, triceps, and quadriceps before and after the program. Strength, jump height, and endurance were also tested to see whether <a href="https://www.earth.com/news/exercise-fuels-neuron-growth-through-muscle-signals/">muscles</a> not only grew but performed better.



Half the group lifted until they could not complete another strict repetition, a strategy known as <a href="https://www.earth.com/news/weight-training-shields-the-aging-brain-from-dementia/">training</a> to failure. The other half stopped two reps short, counting repetitions in reserve as a safety buffer for joints and nerves.



“In our study, the workouts were sufficiently hard to challenge the participants’ muscles beyond their present capacity,” said Schoenfeld. 



Both muscle training strategies enlarged muscle fibers to a similar degree, supporting earlier <a href="https://pubmed.ncbi.nlm.nih.gov/30558493/" target="_blank" rel="noreferrer noopener">work</a> showing that frequency and intensity make only small differences once weekly volume matches. 



A follow‑up analysis found that participants improved their ability to guess how many reps they had left, a skill that lets lifters train hard while avoiding form breakdown. That insight could help gym‑goers monitor effort without fancy devices.



<h2 class="wp-block-heading" id="h-muscle-training-to-failure-vs-holding-back">Muscle training to failure vs holding back</h2>



Going to failure did provide a slight boost in vertical jump power, hinting that maximum effort might recruit more fast‑twitch fibers. 



A 2021 systematic <a href="https://pubmed.ncbi.nlm.nih.gov/33497853/" target="_blank" rel="noreferrer noopener">review</a> echoed that idea but found little extra benefit for arm or leg size when sets finished one or two reps shy.



“By shortening the recovery time, it drives up metabolic stress,” noted <a href="https://publichealth.buffalo.edu/exercise-and-nutrition-sciences/faculty-and-staff/faculty-directory/lpryor.html" target="_blank" rel="noreferrer noopener">Luke Pryor</a>, clinical associate professor of exercise and nutrition sciences at the <a href="https://www.buffalo.edu/" target="_blank" rel="noreferrer noopener">University at Buffalo</a>. 



Metabolic by‑products like lactate and hydrogen ions may act as growth signals when they accumulate quickly.



Another <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8884877/" target="_blank" rel="noreferrer noopener">review</a> from 2023 concluded that training frequency between one and three times per week yields comparable hypertrophy if the total number of quality sets is constant. 



That means busy professionals can cluster their lifts into two focused sessions and still progress.



Athletes chasing power for sprinting or jumping might sprinkle a third day of explosive work. Recreational lifters, however, can choose the schedule that fits job and family demands without fearing slower results.



<h2 class="wp-block-heading" id="h-muscle-training-for-time-pressed-people">Muscle training for time‑pressed people</h2>



Select compound patterns such as squats, deadlifts, pushups, rows, and pullups, because they rally multiple joints and force the body to use more weight. Keep rests shorter than two minutes to maintain the thirty‑minute ceiling.



“I repeat this often: It doesn’t have to be the most to have a benefit,” said <a href="https://sohostrengthlab.com/bios/albert-matheny/" target="_blank" rel="noreferrer noopener">Albert Matheny, RD, CSCS</a>, co‑founder of <a href="https://sohostrengthlab.com/" target="_blank" rel="noreferrer noopener">SoHo Strength Lab</a>. Starting light lets newcomers learn form while still nudging muscles in the right direction.



<a href="https://frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.789403/full" target="_blank" rel="noreferrer noopener">Evidence</a> from 2022 shows that even two thirteen‑minute workouts can raise lean mass if they reach a hard effort, an encouraging benchmark for people who dread long sessions. Once technique improves, individuals can add a warm‑up set or increase load to keep progress steady.



Strength work does more than shape arms. It preserves bone density, raises insulin sensitivity, and helps older adults stay independent. 



The <a href="https://www.cdc.gov/physical-activity-basics/adding-adults/what-counts.html" target="_blank" rel="noreferrer noopener">CDC</a> lists reduced anxiety, better sleep, and a lower risk of chronic disease among the bonuses of regular resistance training. Those benefits kick in long before a mirror shows new definition.



<h2 class="wp-block-heading" id="h-questions-that-remain">Questions that remain</h2>



The present study used mostly machine <a href="https://www.earth.com/news/resistance-exercise-may-be-the-secret-to-relieving-depression/">exercises</a>, which guide motion and reduce stabilizer demand. Future trials will need to confirm whether free‑weight circuits of equal length give the same payoff.



The sample averaged twenty‑seven years old and had at least a year of lifting experience. Researchers will test the protocol in beginners and older adults, groups who often struggle to meet activity guidelines.



Scientists also want to track hormones like testosterone and growth hormone during such brief workouts, along with markers of satellite cell activation. Those data could explain why some <a href="https://www.earth.com/news/eating-grapes-every-day-can-transform-your-muscles/">muscles</a> adapt faster than others.



For now, the simplest plan stands: warm up, pick nine movements that cover the whole body, perform eight to ten deliberate reps, and close the gym bag after thirty minutes. Consistency beats elaborate programming when the clock is tight.



The study is published in <a href="https://journals.lww.com/acsm-msse/abstract/9900/without_fail__muscular_adaptations_in_single_set.782.aspx" target="_blank" rel="noreferrer noopener">Medicine &amp; Science in Sports &amp; Exercise</a>.



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Study learns the exact amount of time you should train to build muscle

Many people still believe that building muscle means living at...

From bright planets to a mythological bird soaring among the stars, July 2025 has an exciting show lined up in the night sky.&nbsp;



NASA’s Jet Propulsion Laboratory (<a href="https://science.nasa.gov/skywatching/whats-up/">JPL</a>) has shared its skywatching highlights - revealing what to be on the lookout for this month, from sunset to sunrise.



<h2 class="wp-block-heading" id="h-planets-in-motion">Planets in motion</h2>



Venus reigns in the morning sky all month, shining brightly in the east during the hours before sunrise. Look for it near the Pleiades star cluster and two brilliant stars - Aldebaran and Capella.



<a href="https://www.earth.com/news/mars-lost-most-of-its-water-but-where-did-it-go/">Mars</a> is visible in the western sky shortly after sunset, glowing about 20 degrees above the horizon before it sets a couple of hours later. On July 28, it forms a striking pair with the crescent Moon.



Jupiter begins to climb into the morning sky after mid-month. Initially low on the eastern horizon, it rises higher each day, heading toward a dramatic August conjunction with Venus.



Mercury is visible only briefly - watch for it in the west during the first week of July, beginning about 30 to 45 minutes after sunset. It stays close to the horizon and sets quickly, so timing and a clear view are key.



<a href="https://www.earth.com/news/massive-energy-imbalance-discovered-on-saturn/">Saturn</a> makes its entrance around midnight and climbs high in the southern sky by dawn - offering a glimpse of the planet for early risers.



<figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"><div class="wp-block-embed__wrapper">
https://youtu.be/SQu8utmfOQk?si=IG-nb7ithbJF3vQD
</div><figcaption class="wp-element-caption">What are some skywatching highlights in July 2025? Look for Mars in the evening, Venus and Jupiter in the morning, and find the eagle constellation, Aquila, soaring overhead.</figcaption></figure>



<h2 class="wp-block-heading" id="h-the-first-successful-mars-mission">The first successful Mars mission</h2>



July 2025 marks the 60th anniversary of NASA’s Mariner 4 mission, which performed the first successful Mars flyby in 1965. 



The spacecraft sent back the first close-up images of the Martian surface and revealed that the planet’s atmosphere was thin, cold, and not as Earth-like as once imagined.&nbsp;



Before Mariner 4, many scientists and the public still held out hope that Mars might resemble a second Earth - perhaps even supporting vegetation or signs of life.&nbsp;



However, the grainy black-and-white images, showing a cratered, barren landscape, were a sobering reality check that reshaped our understanding of the Red Planet.



Despite dashing earlier hopes, Mariner 4 paved the way for decades of <a href="https://www.earth.com/news/climate-collapse-why-did-mars-become-a-desert/">Mars</a> exploration. It was the first time humans had seen another planet up close. The mission proved that long-distance robotic exploration was not only possible, but essential.&nbsp;



<h2 class="wp-block-heading" id="h-spotting-aquila-in-the-july-sky">Spotting Aquila in the July sky</h2>



July is also the ideal time to view Aquila, the Eagle constellation, in the eastern sky during the first half of the night. Its brightest star, Altair, is easy to spot and forms part of the Summer Triangle, along with Vega and Deneb.



Aquila represents the eagle of Zeus in Greek mythology - a powerful messenger and symbol of divine strength. 



Altair marks the eagle’s heart, with its wings stretching wide across the night sky. To find it, look for the triangle-shaped pattern and note that Altair sits at the southern point.



While Aquila’s other stars aren’t as bright, they’re easier to trace under dark skies. The second half of July is especially good for observing this constellation, as the <a href="https://www.earth.com/news/how-did-earth-get-its-moon-a-new-theory-has-emerged/">Moon</a> rises later and leaves the early night sky darker.



For those in the Northern Hemisphere, Aquila is a summer favorite. Once you’ve located Altair, try to follow the eagle’s full wingspan across the sky. It appears to fly northward with its wings outstretched.



<h2 class="wp-block-heading" id="h-key-dates-for-july-skywatching-nbsp">Key dates for July skywatching&nbsp;</h2>



<ul class="wp-block-list">
<li>July 1–7: Mercury is bright and easy to spot in the west after sunset - if you catch it in time. It vanishes within an hour of sundown.</li>



<li>July 21–22: Look east before sunrise to see Venus and Jupiter joined by a crescent Moon, along with several bright stars.</li>



<li>July 28: In the evening sky, the Moon passes close to Mars, offering a beautiful pairing.</li>
</ul>



Whether you’re watching Mars fade into the west or spotting Venus and <a href="https://www.earth.com/news/jupiters-past-how-the-young-gas-giant-shaped-our-solar-system/">Jupiter</a> at dawn, July will be a rewarding month to keep an eye on the sky.&nbsp;



NASA’s monthly “What’s Up” guide helps us stay connected to the ever-changing night sky. To explore more about NASA’s space missions and skywatching tools, visit <a href="https://science.nasa.gov">science.nasa.gov</a>.



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July 2025 skywatching: Bright planets and a summer constellation 

From bright planets to a mythological bird soaring among the...

Farming in ways that support nature can pay off - not just for the environment, but for crops too. That’s the takeaway from a new study that tested how different methods of agroecological farming perform on real working farms in England. 



The study showed that adding simple nature-friendly features like wildflower margins and organic matter improved biodiversity and led to stronger crop performance.



But there’s a catch: to make these methods financially viable on a large scale, many farmers may need more government support.



<h2 class="wp-block-heading" id="h-real-farms-real-results">Real farms, real results</h2>



The research team, based at the <a href="https://www.ceh.ac.uk/">UK Centre for Ecology &amp; Hydrology</a> and Rothamsted Research, ran a four-year study across 17 commercial farms in southern England. This was the first time anyone tested both the ecological and financial impacts of <a href="https://www.earth.com/news/sustainable-farming-is-good-for-farmers-well-being/">agroecological</a> practices at this scale in the UK.



The researchers didn’t just run lab trials. The researchers partnered directly with farmers to design and carry out real-world experiments, testing three types of farming systems side by side.



The first was a business-as-usual approach, using standard intensive methods without any nature-friendly additions. 



The second, called the enhanced ecological system, introduced wildflower field margins to support pollinators and other beneficial insects, along with overwinter cover crops to protect and enrich the soil. 



The third was the maximized ecological system, which built on the enhanced version by adding wildflower strips within the fields - essentially creating insect “runways” - and using farmyard <a href="https://www.earth.com/news/beer-byproducts-and-manure-used-to-increase-crop-yields/">manure</a> to improve soil health.



<h2 class="wp-block-heading" id="h-more-bugs-better-soil-higher-yields">More bugs, better soil, higher yields</h2>



The results were clear. The farms that adopted enhanced or maximized ecological methods saw an increase in beneficial species. 



Earthworms, bees, hoverflies, ladybirds, spiders, and lacewings were all more abundant. These helped reduce crop pests like aphids and snails.



That’s not all. The flowering crops - like oilseed rape - produced more seeds thanks to better pollination. The soils held more carbon. And overall, the yields went up.



Even with a little land taken out of production to make room for habitats, the gains in crop health and pollination made a difference. The enhanced ecological system was just as profitable as conventional farming - but only because of current government subsidies.



The maximized system delivered even stronger environmental and yield benefits. But it was more expensive to implement. 



Without more support, most farms would not find it financially competitive. Some farms, especially mixed ones that already have manure on hand, might fare better. But others would struggle without extra help.



<h2 class="wp-block-heading" id="h-profit-meets-sustainability">Profit meets sustainability</h2>



Dr. Ben Woodcock, one of the study’s lead scientists from the UK Centre for Ecology &amp; Hydrology, elaborated on the research.



“Without the introduction of new financial incentives, many farmers will be deterred from adopting agroecological farming practices and systems. This could leave them locked into high input, intensive farming systems and more exposed to the impacts of pesticide resistance, declining soil health and climate change."



According to Dr. Woodcock, while farmers run businesses that need to be profitable, there is an increasing awareness that more sustainable systems can help "future-proof" their farms in terms of soil health, less reliance on <a href="https://www.earth.com/news/pesticides-attack-bees-in-multiple-ways-throughout-the-body/">pesticides</a> and climate change.



“Agroecological methods are good for biodiversity, food security, and, in the long-term, provide more secure farm incomes but habitats can take several years to establish, so agri-environment subsidies are essential to helping farmers transition to these more sustainable systems.”



<h2 class="wp-block-heading" id="h-support-for-greener-farming">Support for greener farming</h2>



The researchers believe that showcasing these successful results could help convince more farmers to make the switch. It’s about breaking the cycle of intensive practices that keep farms dependent on chemical inputs and vulnerable to environmental changes.



Professor Jonathan Storkey, an ecologist at Rothamsted Research, said the study confirmed that managing land on farms for <a href="https://www.earth.com/news/farming-for-wildlife-how-traditional-practices-can-protect-nature/">wildlife</a> is not in direct conflict with food security but can support sustainable production by increasing yields and reducing pest pressure. 



"These ‘ecosystem services’ could potentially substitute for chemical fertilizers and pesticides which negatively impact the environment," said Professor Storkey. 



“However, our analysis has shown that realizing these benefits will require additional support for farm businesses that currently operate on very narrow profit margins. As input costs increase, however, these agroecological approaches may become more attractive.”



<h2 class="wp-block-heading" id="h-training-makes-a-difference">Training makes a difference</h2>



The quality of nature-friendly measures also depends on how well they’re implemented, and training helps.



Earlier research from the UK Centre for Ecology &amp; Hydrology showed that when farmers receive proper guidance on creating and managing wildlife habitats, those habitats do a much better job of supporting <a href="https://www.earth.com/news/how-pollinators-boost-the-nutritional-value-of-crops/">pollinators</a> and pest-controlling insects.



Field margins and wildflower strips may seem like simple changes, but getting them right requires different thinking than managing crops. The better these habitats are planned and maintained, the more they deliver.



<h2 class="wp-block-heading" id="h-growing-green-nationwide">Growing green, nationwide</h2>



Nature-friendly farming isn’t just about doing good for the environment - it can also help farms thrive. But making the switch isn’t free, and for many farmers, the numbers have to work. 



That’s where targeted subsidies and support come in. The research shows what’s possible. Now, the question is how to make it doable for more farms across the country.



The full study was published in the journal <a href="https://besjournals.onlinelibrary.wiley.com/doi/10.1111/1365-2664.70079">Journal of Applied Ecology</a>.



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Eco-friendly farms can succeed - but they need support

Farming in ways that support nature can pay off -...

Music can make a sleepy train ride feel romantic or turn a routine workout into an emotional burst of energy. 



Scientists have long wondered how a string of notes pushes the brain from one emotional <a href="https://www.earth.com/news/our-brain-doesnt-just-hear-music-it-becomes-the-rhythm/">feeling</a> to the next, and why the experience changes when the previous feeling was different. <a href="https://psychology.columbia.edu/content/matthew-sachs" target="_blank" rel="noreferrer noopener">Matthew Sachs</a> of Columbia University and colleagues set out to <a href="https://www.eneuro.org/content/early/2025/06/19/ENEURO.0184-24.2025" target="_blank" rel="noreferrer noopener">answer</a> that puzzle.



<h2 class="wp-block-heading" id="h-a-wordless-path-to-emotion">A wordless path to emotion</h2>



Music reliably raises specific <a href="https://pubmed.ncbi.nlm.nih.gov/32898679/" target="_blank" rel="noreferrer noopener">emotions</a> across cultures, making it a useful tool for lab work. Because melodies lack words, researchers can study pure feeling without the baggage of stories or language.



In recent <a href="https://www.pnas.org/doi/10.1073/pnas.1910704117" target="_blank" rel="noreferrer noopener">surveys</a>, listeners reported at least thirteen distinct emotional colors from songs, ranging from awe to tenderness. Those varied reactions let scientists choreograph controlled “emotional journeys” by arranging passages that lean happy, tense, calm, or sad.



The brain also treats music as a social signal, recruiting regions tied to empathy and perspective‑taking. That overlap makes findings with music relevant to understanding everyday interactions. 



Music’s precise timing helps investigators lock brain activity to exact seconds in a tune. Such temporal precision is important when studying transitions, which can unfold in a blink.



Finally, unlike pictures or movies, songs can be replayed in multiple orders without breaking logic. That flexibility allowed the team to test how a given passage feels when it follows joy versus when it follows anxiety.



<h2 class="wp-block-heading" id="h-music-changes-emotion-fast">Music changes emotion fast</h2>



Sachs’s group asked professional composers to craft two fifteen‑minute pieces split into thirty‑two “emotion events,” each one lasting about 30‑70 seconds. The passages covered calm, joy, sadness, anxiety, and a mixed nostalgic <a href="https://www.earth.com/news/live-music-connects-people-emotionally-and-physically/">feeling</a>.



Two versions of each piece shuffled the same events so that a joyful segment might follow calm in one version but chase sadness in the other. 



This context swap let the researchers isolate the effect of prior mood. Thirty‑nine volunteers lay in an <a href="https://my.clevelandclinic.org/health/diagnostics/25034-functional-mri-fmri" target="_blank" rel="noreferrer noopener">fMRI scanner</a>, a technique that tracks blood flow as a stand‑in for neural activity. The scanner’s pulses were timed to the beat so listeners heard smooth audio through special headphones.



After scanning, the volunteers replayed short clips of music online and rated how strongly each clip made them feel the target emotion. Those ratings confirmed that the music hit its emotional marks at the intended moments.



To align brains that never look identical, the team used a <a href="https://web.stanford.edu/~jurafsky/slp3/A.pdf" target="_blank" rel="noreferrer noopener">Hidden Markov model</a>, a statistical tool that spots stable patterns and the moments they shift. The model does not assume equal event lengths, matching how real feelings vary.



<h2 class="wp-block-heading" id="h-music-mapped-onto-brain-activity">Music mapped onto brain activity</h2>



Activity patterns in auditory cortex and the adjoining superior temporal gyrus stayed steady within an event but flipped sharply at composer‑defined boundaries. Those flips still appeared after factoring out pitch, volume, and harmony, meaning the brain was tracking emotion rather than mere <a href="https://www.earth.com/news/music-and-repeated-sounds-reorganize-your-brain-networks-in-real-time/">acoustics</a>.



The same temporal‑parietal strip has been linked to social meaning in speech and laughter. Current <a href="https://www.sciencedirect.com/science/article/pii/S0896627317305937" target="_blank" rel="noreferrer noopener">findings</a> add music‑evoked emotion dynamics to its résumé. 



Elsewhere, frontal regions associated with self‑reflection lit up when feelings changed. That response supports prior work showing prefrontal roles in labeling and regulating emotion.



Importantly, <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2768874/" target="_blank" rel="noreferrer noopener">subcortical reward hubs</a> showed general arousal but did not map fine‑grained transitions. Those areas may mark intensity rather than shifts in category. 



Together the data sketch a layered system: auditory regions sense change, temporal‑parietal regions label the new state, and frontal areas integrate the experience. That hierarchy resembles proposed models for narrative comprehension.



<h2 class="wp-block-heading" id="h-past-emotions-change-how-you-hear-music">Past emotions change how you hear music</h2>



When a happy passage followed another positive passage, listeners’ brains switched to the new state about six seconds sooner than when the same passage followed a tense one. The volunteers also pressed the “happy” button nine seconds earlier in the same‑valence condition.



Context even changed the spatial pattern of activity during an event. Pairs of participants who heard a clip in the same order showed more similar neural signatures than pairs who heard it in opposite orders.



Such carry‑over echoes psychological <a href="https://pubmed.ncbi.nlm.nih.gov/31628982/" target="_blank" rel="noreferrer noopener">findings</a> that earlier feelings bias how we perceive later stimuli. The study quantifies that bias down to single‑second resolution. 



Researchers call the stickiness of mood <a href="https://econtent.hogrefe.com/doi/10.1027/0269-8803.23.1.7" target="_blank" rel="noreferrer noopener">valence</a> persistence, and extreme persistence can tip into emotional rigidity. Depression is often marked by this rigidity, trapping individuals in negative states.



<h2 class="wp-block-heading" id="h-treating-emotion-with-playlists">Treating emotion with playlists</h2>



“We know that people who suffer from mood disorders or depression often demonstrate emotional rigidity, where they basically get stuck in an emotional state" said Sachs. 



"Maybe we could take someone with depression, for instance, and use the approach we developed to identify neural markers for the emotional rigidity that keeps them in a very negative state.”



His comment matches growing interest in music‑based interventions. Unlike medications, playlists can be tailored rapidly and have few side effects. 



If clinicians can spot delayed transition signatures in vulnerable patients, they might train quicker shifts through neurofeedback. Past <a href="https://pubmed.ncbi.nlm.nih.gov/19646532/" target="_blank" rel="noreferrer noopener">work</a> shows that people can learn to nudge targeted brain regions with real‑time feedback.



Therapists already use mood‑tracking apps; adding objective brain markers could improve accuracy. Personalized “emotion workouts” might teach flexible switching, similar to cognitive training for attention.



 Beyond clinics, the findings could improve soundtracks in virtual reality or adaptive <a href="https://www.earth.com/news/video-games-can-rewind-the-clock-on-cognitive-performance/">games</a>. Systems might adjust musical cues to help users linger in, or exit from, certain feelings.



<h2 class="wp-block-heading" id="h-what-science-hasn-t-tested-yet">What science hasn’t tested yet</h2>



The study focused on adults in a scanner; children, musicians, or people with disorders may show different timelines. Future projects could compare those groups directly.&nbsp;



Only five emotion labels were used. Real life holds many blended states such as awe or envy that might map differently. Subcortical areas did not show clear transition patterns here, but that may reflect scanner noise or event length.&nbsp;



Higher‑resolution recordings could reveal subtler dynamics. Music is just one trigger; spoken stories, movement, or smell might drive other networks. 



Combining modalities could pinpoint common versus unique pathways. Finally, the team manipulated valence but not arousal. Experiments that cross calm‑excited levels might tease apart the role of energy versus positivity.



The study is published in <a href="https://www.eneuro.org/content/early/2025/06/19/ENEURO.0184-24.2025" target="_blank" rel="noreferrer noopener">eNeuro</a>.



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Music rewires the brain to quickly navigate emotion

Music can make a sleepy train ride feel romantic or...

For nearly a century, brominated vegetable oil - better known as BVO - helped keep that sharp, zesty taste of citrus-flavored sodas evenly distributed from the first sip to the last. 



Most shoppers never noticed the name on ingredient lists, and few paused to wonder why a cooking oil had been blended with <a href="https://pubchem.ncbi.nlm.nih.gov/compound/Bromine" target="_blank" rel="noreferrer noopener">bromine</a>, a heavy chemical element more often associated with pool disinfectants than with beverages.



Over the past year, though, BVO has moved from obscurity into the spotlight. New toxicology studies forced the U.S. Food and Drug Administration (<a href="https://www.fda.gov/" target="_blank" rel="noreferrer noopener">FDA</a>) to take a hard second look at an additive it once allowed at up to 15 parts per million. 



The agency’s verdict set off a countdown: <a href="https://www.earth.com/news/soda-taxes-actually-work-improving-both-health-and-mindset/">all sodas</a> sold after August 2, 2025, must be BVO-free, shutting the door on a substance that first slipped into fizz back in the 1930s.



<h2 class="wp-block-heading" id="h-citrus-sodas-and-bvo">Citrus sodas and BVO</h2>



Public worries about <a href="https://cris.msu.edu/news/trending/trending-brominated-vegetable-oil-bvo/" target="_blank" rel="noreferrer noopener">brominated vegetable oil</a> started decades ago, when researchers spotted bromine accumulating in human tissue samples taken in the United Kingdom during the 1970s. Animal studies soon linked high BVO intakes with heart and behavioral problems. 



Even so, the FDA kept the ingredient on a short leash rather than banning it outright, capping concentrations and labeling it “interim” while scientists gathered more data. The arrangement limped along for half a century.



Fresh evidence tipped the scale. A 90-day study funded by the FDA and the National Institutes of Health (<a href="https://www.nih.gov/" target="_blank" rel="noreferrer noopener">NIH</a>) tracked rats fed diets ranging from zero to high levels of BVO. 



Bromine not only flooded their bloodstreams but also settled in the heart, liver, and body fat. Thyroid cells enlarged, thyroid-stimulating hormone climbed, and T4 hormone dipped, hinting at metabolic trouble ahead.



<h2 class="wp-block-heading" id="h-why-brominated-oils-raised-alarms">Why brominated oils raised alarms</h2>



<a href="https://www.earth.com/news/eating-seafood-helps-children-develop-better-social-behaviors/">Thyroid shifts</a> matter because that small gland choreographs energy levels, growth, and mood. When bromine crowds out iodine - its chemical cousin - hormone production stumbles. 



Researchers worry that even subtle, long-term interference could nudge people toward weight gain, sluggishness, and <a href="https://www.earth.com/news/unhealthy-diet-leaves-brain-feeling-foggy-frazzled-sad/">brain fog</a>. 



Because bromine accumulates rather than being flushed straight through, the risk grows the longer someone drinks BVO-laced sodas.



Most major brands ditched BVO years ago. PepsiCo pulled it from Gatorade in 2013 and from Mountain Dew soon after. Coca-Cola quietly reformulated Fanta and Powerade. 



Yet store-brand and regional citrus sodas sometimes clung to the old recipe. In mid-2024, Keurig Dr. Pepper still listed BVO in Sun Drop, though the company pledged to roll out a new formula before year’s end.



<h2 class="wp-block-heading" id="h-fda-ruling-s-impact-on-bvo-sodas">FDA ruling's impact on BVO sodas</h2>



<a href="https://foodsafety.gwu.edu/jim-jones">James Jones</a>, deputy commissioner for human foods, summed up the agency’s thinking: “The proposed action is an example of how the agency monitors emerging evidence and, as needed, conducts scientific research to investigate safety-related questions, and takes regulatory action when the science does not support the continued safe use of additives in foods.” 



The final rule arrived on July 3, 2024, and became effective a month later, with a one-year grace period to drain warehouses and reset production lines.



Between now and August 2, 2025, shoppers can still run into cans made before the deadline. 



The safest approach is old-fashioned label reading - look for “brominated vegetable oil” or “<a href="https://www.sciencedirect.com/science/article/abs/pii/0300483X76900512" target="_blank" rel="noreferrer noopener">brominated soybean oil</a>.” After that date, any product that still lists the additive will be pulled from shelves.



<h2 class="wp-block-heading" id="h-how-beverage-makers-responded">How beverage makers responded</h2>



For companies, swapping out BVO meant finding other ways to keep citrus oils suspended. Many turned to ingredients already common in European and Japanese drinks, where BVO has been banned for years. 



<a href="https://www.sciencedirect.com/science/article/abs/pii/S0278691597803055" target="_blank" rel="noreferrer noopener">Sucrose acetate isobutyrate</a> and glycerol ester of wood rosin (<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7009419/" target="_blank" rel="noreferrer noopener">GEWR</a>) emerged as the go-to solutions; both create a dense phase that marries well with fruit oils without relying on bromine. 



Because the substitutes have long safety records abroad, the transition proved smoother than earlier label rewrites involving artificial dyes.



Retailers responded in parallel. National grocery chains began flagging private-label SKUs that needed reformulation, giving suppliers early notice. 



Craft <a href="https://www.earth.com/news/ultra-processed-foods-like-soda-and-snacks-are-the-new-silent-killer/">soda makers</a>, eager to stand out in a crowded aisle, advertised “BVO-free” right on the front of the bottle, turning regulatory compliance into a selling point.



<h2 class="wp-block-heading" id="h-what-science-says-about-bvo">What science says about BVO</h2>



Several studies over the years had very similar results. Bromine lodged in organs after only three months, a blip compared with human drinking habits that can stretch across decades. 



The thyroid, sensitive to iodine balance, responded quickly. Researchers did not observe tumors or acute poisoning, but the hormonal disruptions alone convinced regulators that routine consumption no longer passed the sniff test.



Back in the 1950s, the FDA first labeled BVO “<a href="https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras" target="_blank" rel="noreferrer noopener">generally recognized as safe</a>,” largely because citrus sodas were already popular. 



By 1970, the agency had reversed its stance, restricting use to citrus drinks and setting the 15-parts-per-million ceiling. Subsequent studies, including one published on May 16, 2022, in Food and Chemical Toxicology, kept adding red flags. 



Taken together, the evidence portrays a slow-burn risk rather than an immediate hazard - yet that is exactly the kind of threat public health agencies try to prevent.



<h2 class="wp-block-heading" id="h-changes-in-the-u-s-food-code">Changes in the U.S. food code</h2>



The BVO saga hints at future shake-ups in the U.S. food code. The FDA is reassessing a roster of additives, with an eye toward automatic bans on <a href="https://www.earth.com/news/one-in-five-packaged-foods-in-the-u-s-contains-synthetic-dyes/">colorants that cause cancer</a> in animals. 



Speeding up that process would spare consumers from the long twilight period BVO endured. 



For beverage developers, the lesson is clear: lean on ingredients with global acceptance, and keep an eye on toxicology journals as closely as on flavor-trend reports.



By August 2025, American citrus sodas will taste the same to most palates, but the chemistry behind that flavor will have changed. 



With no more swimming pool disinfectants like bromine in your beverages, the drink industry inches toward simpler, more transparent labels - something shoppers have been thirsting for as much as the fizz itself.



The full study was published in the journal <a href="https://www.sciencedirect.com/science/article/abs/pii/S0278691522003350" target="_blank" rel="noreferrer noopener">Food and Chemical Toxicity</a>.



Read the <a href="https://www.fda.gov/food/food-additives-petitions/brominated-vegetable-oil-bvo" target="_blank" rel="noreferrer noopener">The U.S. FDA ruling on BVO</a>.



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FDA ban on highly toxic soda ingredient finally goes into effect this month

For nearly a century, brominated vegetable oil - better known...

Far below the ocean’s surface, the Great Barrier Reef hums with life. It is not just about colorful fish or vibrant corals. Something else is happening that we cannot see.



Tiny <a href="https://www.earth.com/news/world-reef-awareness-day-2025-bringing-corals-back-to-life/">coral</a> larvae drift in the currents, carried away from their parents. Some travel far and some barely move at all. Where these larvae end up can decide the fate of entire reefs.



Now, scientists from the <a href="https://www.uq.edu.au" target="_blank" rel="noreferrer noopener">University of Queensland</a> have unlocked a key mystery. Their new study shows how far these baby corals can go. The research also reveals why this matters more than we ever realized.



<h2 class="wp-block-heading" id="h-why-some-coral-babies-survive">Why some coral babies survive</h2>



<a href="https://www.earth.com/news/wild-temperature-swings-boost-coral-reef-resilience/">Corals</a> are under pressure. Heatwaves damage them. Storms cause destruction. Oceans keep getting more acidic. Each year, the risk becomes worse. But not all corals are affected equally. PhD candidate Zoe Meziere explained why some reefs survive better than others.



“Quantifying genetic connectivity can predict the fate of populations as more isolated reefs with lower levels of genetic variation are likely more vulnerable,” said Meziere.



When coral species spread their larvae far, they swap genetic material with distant reefs. This boosts their ability to adapt and recover. Corals that keep their offspring close face greater risks. They may struggle to bounce back after disasters.



<h2 class="wp-block-heading" id="h-coral-species-take-different-paths">Coral species take different paths</h2>



Meziere and her team searched for answers. They focused on two coral species found across the Great Barrier Reef, Stylophora pistillata and Pocillopora verrucosa.



The <a href="https://www.earth.com/news/fossils-reveal-how-humans-completely-changed-caribbean-reef-ecosystems/">species</a> live near each other, but their ways of reproducing could not be more different. Stylophora pistillata plays it safe. It fertilizes its eggs internally. Its larvae do not venture far. Most settle nearby, just meters from their parent colony.



Pocillopora verrucosa does the opposite. It releases eggs and sperm into the sea. Currents carry its larvae far from home.



The results surprised the researchers. Stylophora pistillata larvae traveled only 23 to 102 meters. Pocillopora verrucosa larvae journeyed as far as 52 kilometers.



Professor Cynthia Riginos noted that this is the first study to quantify how connected different coral populations are across the seascape.



<h2 class="wp-block-heading" id="h-why-the-journey-of-baby-corals-matters">Why the journey of baby corals matters</h2>



The story does not stop with distance. These differences shape the future of coral populations.



Stylophora pistillata stays close to home. It forms small, tight populations. Over time, these groups grow isolated. They lose genetic diversity. That leaves them vulnerable. Pocillopora verrucosa travels widely. It links distant populations. This mixing keeps its populations strong and diverse.



“Over time, these differences have profound evolutionary impacts with S. pistillata populations being more genetically distinctive with much lower genetic diversity and smaller population sizes than the more widely dispersing P. verrucosa,” explained Professor Riginos.



<h2 class="wp-block-heading" id="h-where-baby-corals-travel">Where baby corals travel</h2>



The research team did not stop after measuring dispersal. They looked deeper into the genetic maps.



Stylophora pistillata stayed loyal to its local area. Its genetic patterns showed clear boundaries between reefs. Neighboring reefs looked genetically distinct. 



Pocillopora verrucosa showed no such boundaries. Its populations mixed freely throughout the reef. From one end to another, its genetics stayed consistent.



S. pistillata’s world spanned just a few hundred meters, while P. verrucosa’s world stretched across tens of kilometers.



<h2 class="wp-block-heading" id="h-coral-survival-and-recovery">Coral survival and recovery</h2>



Distance is only part of the story. Gene flow also plays a big role. S. pistillata had weak gene flow. Its reefs relied mostly on themselves. This isolation put them at risk. One disaster could wipe out an entire population with no outside help.



P. verrucosa showed strong gene flow, as distant reefs shared genes often. This flow allowed for faster recovery after disasters.



This means that Pocillopora verrucosa can bounce back after bleaching far more quickly than Stylophora pistillata.



<h2 class="wp-block-heading" id="h-some-coral-babies-stay-stronger">Some coral babies stay stronger</h2>



Genetic diversity matters for survival. The researchers found striking differences here too.



Stylophora pistillata had low genetic <a href="https://www.earth.com/news/ancient-coral-collapse-may-help-save-the-great-barrier-reef/">diversity</a>. Its diversity also varied wildly between reefs. The lowest levels appeared in southern parts of the Great Barrier Reef.



Pocillopora verrucosa held onto high diversity. Its genetic richness stayed stable across all reefs. S. pistillata lives in a fragile world, and P. verrucosa thrives in a far more connected one.



<h2 class="wp-block-heading" id="h-smarter-conservation-for-corals">Smarter conservation for corals</h2>



The research offers a clear message for coral conservation efforts. Stylophora pistillata needs focused, local protection. Efforts must center on preserving nearby populations. Without these, this species faces collapse.



Pocillopora verrucosa calls for a broader approach. Large-scale conservation networks can help maintain its natural strength.



"Dispersal and connectivity are important drivers of coral adaptation, and being able to adapt is key to having healthy coral reefs in the future,” said Meziere.



<h2 class="wp-block-heading" id="h-new-approach-to-reef-restoration">New approach to reef restoration</h2>



Coral restoration should not follow a one-size-fits-all model. Stylophora pistillata may benefit from assisted migration. Moving larvae or adult corals from healthy reefs to damaged ones could restore genetic diversity. 



However, such moves must be done carefully. Forcing new genes into a delicate reef might cause new problems.



Pocillopora verrucosa already benefits from strong natural connections. Protecting these migration routes may be enough.



Each coral species has its own needs. These needs are not the same. Conservation efforts should focus on these differences.



<h2 class="wp-block-heading" id="h-new-insights-for-coral-conservation">New insights for coral conservation </h2>



Coral reefs have an uncertain future. Their survival depends on how well we understand and protect the hidden connections between them.



The study, funded by the Australian Government’s Reef Trust and the Great Barrier Reef Foundation, brings new insights to reef science.



The research makes one thing clear: not all corals are the same. Some need protection close to home, while others depend on far-reaching connections. 



The study is published in the journal <a href="https://www.science.org/doi/10.1126/sciadv.adt2066" target="_blank" rel="noreferrer noopener">Science Advances</a>.



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Reef survival may depend on how far baby corals travel

Far below the ocean’s surface, the Great Barrier Reef hums...

Parkinson's,Disease.,3d,Illustration,Showing,Neurons,Containing,Lewy,Bodies,Small

A cancer immunotherapy drug that is already on pharmacy shelves is showing fresh potential in the fight against Parkinson’s disease. 



In mouse experiments, <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2109970">n</a><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2109970" target="_blank" rel="noreferrer noopener">ivo</a><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2109970">lumab–relatlimab</a>, a fixed‑dose antibody combination used for treating melanoma, blocked the cell‑to‑cell spread of toxic protein clumps that drive the disorder.



More than <a href="https://www.who.int/news-room/fact-sheets/detail/parkinson-disease" target="_blank" rel="noreferrer noopener">8.5 million people</a> worldwide are living with <a href="https://www.parkinson.org/" target="_blank" rel="noreferrer noopener">Parkinson’s disease</a>. Current drugs ease symptoms but do little to halt the relentless loss of movement, speech, and independence.



<a href="https://profiles.hopkinsmedicine.org/provider/xiaobo-mao/2777172" target="_blank" rel="noreferrer noopener">Xiaobo Mao</a> of Johns Hopkins University led an international team that traced the blockade to a newly revealed partnership between two brain proteins, Aplp1 and LAG‑3. Their study offers a practical target for slowing disease progression.



<h2 class="wp-block-heading" id="h-how-cancer-drug-blocks-parkinson-s">How cancer drug blocks Parkinson’s</h2>



<a href="https://www.nature.com/articles/s41419-023-05672-9" target="_blank" rel="noreferrer noopener">Alpha‑synuclein</a> normally helps nerve cells chat across synapses, yet when it misfolds it becomes sticky and forms Lewy bodies. 



The group discovered that Aplp1 and LAG‑3 act like twin door handles, swinging the misfolded cargo into neurons together.



“Now that we know how Aplp1 and LAG-3 interact, we have a new way of understanding how alpha‑synuclein contributes to the disease progression of <a href="https://www.earth.com/news/pesticide-exposure-increases-the-risk-of-parkinsons-disease/">Parkinson’s </a>disease,” confirmed Mao.



Deleting either handle in genetically engineered mice cut protein uptake, but deleting both slashed it by 90 percent.



Using cultured neurons, the team showed that antibodies against LAG‑3 disrupted the partnership and kept most toxic fibrils outside. That hint of druggability set the stage for tests with the approved melanoma therapy.



<h2 class="wp-block-heading" id="h-repurposing-a-cancer-drug-for-parkinson-s">Repurposing a cancer drug for Parkinson's</h2>



Nivolumab–relatlimab, marketed as <a href="https://www.opdualag.com/" target="_blank" rel="noreferrer noopener">Opdualag</a>TM, won <a href="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-opdualag-unresectable-or-metastatic-melanoma" target="_blank" rel="noreferrer noopener">FDA clearance</a> in 2022 as the first combination to target PD‑1 and LAG‑3 checkpoints in <a href="https://www.earth.com/news/computer-model-can-identify-tumor-fighting-immune-cells/">tumors</a>.



Because relatlimab binds LAG‑3, the Parkinson’s team wondered whether it could also short‑circuit the neural handshake.



They injected the antibody mix into mice previously dosed with pathogenic fibrils. Treated animals accumulated far fewer Lewy‑like inclusions, keeping the midbrain’s <a href="https://www.earth.com/news/dopamine-enhances-brain-function-during-exercise/">dopamine</a> supply and motor skills intact.



“The anti‑LAG-3 antibody was successful in preventing further spread of alpha‑synuclein seeds in the mouse models,” said <a href="https://profiles.hopkinsmedicine.org/provider/ted-m-dawson/2708436" target="_blank" rel="noreferrer noopener">Ted Dawson</a>, also from Johns Hopkins.



The effect outperformed complete genetic knockout of LAG‑3 because the drug simultaneously disrupted its partner, Aplp1.



<h2 class="wp-block-heading" id="h-a-protein-traffic-jam-in-the-brain">A protein traffic jam in the brain</h2>



The brain’s <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12034127/" target="_blank" rel="noreferrer noopener">substantia nigra</a> houses dopamine‑producing neurons that fine‑tune movement. When alpha‑synuclein fibrils march from cell to cell, these neurons choke and die, triggering tremor and rigidity.



LAG-3 had been flagged as a fibril receptor before, yet blocking it alone left plenty of pathology. The new work clarifies that Aplp1 forms a complex with LAG-3, which creates a high‑affinity docking site for toxic cargo.



By filming neurons with pH‑sensitive dye, researchers watched fibrils enter healthy cells in minutes. Removal of either handle delayed entry, while removal of both stopped it almost completely.



The discovery may explain why single‑target strategies have struggled to translate. Therapies that ignore Aplp1 risk leaving a back‑door route open for disease spread.



<h2 class="wp-block-heading" id="h-why-parkinson-s-is-so-difficult">Why Parkinson's is so difficult</h2>



Parkinson’s is diagnosed only after motor symptoms emerge, by which time over half of nigral dopamine neurons have perished. <a href="https://www.nia.nih.gov/health/lewy-body-dementia/lewy-body-dementia-causes-symptoms-and-diagnosis" target="_blank" rel="noreferrer noopener">Lewy bodies</a> start forming decades earlier and appear to propagate along neural highways.



Scientists debate whether the fibrils cause disease or merely mark dying cells, yet the correlation is strong enough that reducing their spread remains a key goal. 



Animal studies that limit fibril movement often preserve motor behavior and cortical thinking.



The Aplp1–Lag3 duo offers a concise molecular explanation for long‑range propagation. It also supplies a measurable biomarker, their physical interaction, that drug developers can monitor.



<h2 class="wp-block-heading" id="h-antibodies-in-action">Antibodies in action</h2>



Preclinical success seldom guarantees human benefit, yet repurposing an approved therapy skips many safety hurdles. 



Opdualag’sTM pharmacokinetics, dosing, and adverse‑event profile are already mapped in thousands of cancer patients.



The antibody crosses the mouse blood–brain barrier at roughly 0.5 percent of plasma levels, similar to other <a href="https://www.webmd.com/drugs/2/drug-20642/immune-globulin-human-igg-intravenous/details" target="_blank" rel="noreferrer noopener">IgG medicines</a>. That level sufficed to curb fibril uptake and protect motor performance in pole and cylinder tests.



If forthcoming primate and human studies confirm brain penetration, clinicians could move swiftly into small Parkinson’s trials using this cancer treatment drug. Outcome measures might track motor scores, cerebrospinal fibril counts, and imaging of nigral dopamine.



<h2 class="wp-block-heading" id="h-parkinson-s-gets-help-from-cancer-drug">Parkinson's gets help from cancer drug</h2>



<a href="https://www.earth.com/news/light-activated-molecules-kill-cancer-cells-with-precision/">Cancer</a> checkpoint drugs can unleash immune‑related side effects, including rash, thyroid imbalance, and fatigue. Whether similar events would occur at lower neurological doses remains unknown.



Another question is timing. Most <a href="https://www.earth.com/news/reprogramming-the-immune-system-to-attack-cancer-cells/">cancer antibodies</a> are delivered in pulses, whereas chronic neuroprotection for Parkinson's patients might require years of therapy.



Finally, fibril spread is only one facet of Parkinson’s biology. Mitochondrial stress, environmental toxins, and genetics also contribute, so a combination of treatments will likely be needed.



Even so, the ease of testing an off‑the‑shelf cancer medicine for Parkinson's patients makes this avenue irresistible. As Dawson observed, stopping spread “could significantly slow the progression of Parkinson’s disease.”



The study is published in <a href="https://www.nature.com/articles/s41467-024-49016-3" target="_blank" rel="noreferrer noopener">Nature Communications</a>.



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Plants turn air into leaves, roots, and fruit, yet every molecule of the carbon they store has to squeeze through microscopic pores first. These pores, called stomata, dot the surface of nearly every leaf and set the pace for both growth and water loss.



The latest study from <a href="https://www.stanford.edu/" target="_blank" rel="noreferrer noopener">Stanford University</a> shows that each new stoma is the product of a lively conversation among neighboring cells and a hard look in the mirror. 



Dominique Bergmann and her team traced those talks in <a href="https://www.nature.com/articles/35048692" target="_blank" rel="noreferrer noopener">Arabidopsis</a> (Arabidopsis thaliana), the small mustard plant whose genome was first decoded in 2000.



<h2 class="wp-block-heading" id="h-how-plants-form-and-adjust-pores">How plants form and adjust pores</h2>



Stomata behave like adjustable valves, opening when light and water are plentiful and closing when drought or darkness loom. Their numbers are not fixed; plants can make more or fewer during development, tweaking their gas exchange to match the <a href="https://www.earth.com/news/how-future-climate-conditions-will-transform-plant-growth/">environment</a>.



For that plasticity to work, precursor cells must decide whether to divide again or settle down as part of the pavement around a stoma. 



The new research focuses on these larger daughters, called stomatal lineage ground cells, which had been thought to be passive passengers in <a href="https://www.earth.com/news/plants-use-sugar-in-ways-we-never-imagined/">leaf</a> development.



The Stanford team captured day‑long movies of living leaves and tracked every fate choice. They discovered that the future of each cell depends on its own size and on the crowd of neighbors encircling it.



<h2 class="wp-block-heading" id="h-plants-use-nearby-cells-to-control-pores">Plants use nearby cells to control pores</h2>



Signals drift through the leaf in the form of tiny peptides such as <a href="https://pubmed.ncbi.nlm.nih.gov/20010603/" target="_blank" rel="noreferrer noopener">epidermal patterning factor 1</a> (EPF1) and its sibling EPF2, which tell nearby cells to slow down or stop forming new stomata. 



Because these messages travel only a short distance, the number of stomatal precursors touching a cell sets the strength of the “slow down” order.



Cells bordered by two or more precursors received a louder signal and dismantled an internal protein called <a href="https://www.sciencedirect.com/science/article/pii/S0960982218302392" target="_blank" rel="noreferrer noopener">SPEECHLESS</a> before it could trigger another split. Those with just one signaling neighbor heard only a whisper and often went on to divide again.



The researchers measured how fast SPEECHLESS disappeared and found that the rate jumped with every extra neighbor. By evening, many well‑connected cells had emptied their nuclei of the division‑promoting factor and settled into a quiet <a href="https://www.earth.com/news/scientists-finally-learn-what-makes-plants-roots-grow-faster-and-stronger-autophagy/">life</a> as pavement.



<h2 class="wp-block-heading" id="h-the-role-of-cell-size">The role of cell size </h2>



Size turned out to be the second half of the script. When two sister cells emerged from a split, one was noticeably larger and carried a larger nucleus.



Bigger nuclei diluted the amount of SPEECHLESS even before degradation kicked in, pushing the concentration below the threshold needed to spark another round of division. Smaller sisters packed the protein more tightly and were free to keep the lineage going.



To confirm the link, the team boosted SPEECHLESS levels across the board. Large cells that normally would have retired instead re‑entered the cell cycle, proving that concentration, not mere presence, calls the shots.



<h2 class="wp-block-heading" id="h-plants-use-internal-guides-to-shape-pores">Plants use internal guides to shape pores</h2>



“Compasses have dual roles,” said Bergmann. The study builds on earlier work showing that internal “compasses” guide each split so that one daughter remains small and <a href="https://www.earth.com/news/plant-roots-could-be-key-to-fighting-climate-change/">stem</a>‑like while the other grows large.&nbsp;



Bergmann explained that the same molecular north arrow orients the division plane and then reorganizes the contents of the newborn cells to cement their different futures. 



Computational models confirmed that size, neighbor count, and SPEECHLESS levels together predict a cell’s fate better than any factor alone.



Warm nights add another twist: higher temperatures activate a photoreceptor called PIF4 that limits SPEECHLESS production, cutting back the formation of new stomata. 



The Stanford data suggest that heat might tilt the balance further by shrinking protein levels just enough to keep big cells out of the cell cycle.



<h2 class="wp-block-heading" id="h-improving-crops-and-farming">Improving crops and farming</h2>



Why should anyone without a microscope care how many times a leaf cell divides? Because every stoma trades water for carbon, the final stomatal count shapes a crop’s thirst and yield.



Breeders are already lowering <a href="https://pubmed.ncbi.nlm.nih.gov/37923396/" target="_blank" rel="noreferrer noopener">stomatal density</a> in wheat, barley, and rice to save water without hurting photosynthesis. Knowing that cell size and neighbor signals tune those numbers could make such tweaks more precise and less likely to backfire.



The work also hints at strategies for future‑proofing plants against heat waves. If larger precursor cells naturally avoid dividing under high temperature, selecting varieties with slightly bigger epidermal cells could be a subtle way to reduce water loss.



There is an evolutionary angle as well. Fossil leaves show that ancient plants reduced their stomatal density when atmospheric CO₂ climbed, mirroring the choices Bergmann’s cells make on a microscopic scale.



Understanding the cell‑level logic may help scientists read the rock record more accurately and model how modern forests will respond to rising greenhouse gases. It could even inform designs for synthetic leaves or bio‑inspired materials that need self‑regulating pores.



<h2 class="wp-block-heading" id="h-research-on-plants-and-their-pores">Research on plants and their pores</h2>



The Bergmann lab now wants to trace the still‑mysterious signals that link cell size to peptide output. They suspect a size‑sensing pathway unrelated to SPEECHLESS that may give big cells an extra nudge toward differentiation.



If that circuit can be mapped, it might be possible to rewire it, allowing crops to adjust their stomata on demand without penalties in growth. Such control would be a powerful tool in regions where water scarcity and heat routinely threaten harvests.



The study is published in the journal <a href="https://www.nature.com/articles/s41467-025-57730-9" target="_blank" rel="noreferrer noopener">Nature Communications</a>.



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How plants decide where to put their breathing pores

Plants turn air into leaves, roots, and fruit, yet every...

Everyday life is filled with conveniences that many people take for granted. Stain-resistant fabrics, non-stick cookware, and water-repellent items are all around. These products owe their useful properties to a group of synthetic chemicals called per- and polyfluoroalkyl substances, known as PFAS.



While these <a href="https://www.earth.com/news/bacteria-that-eat-forever-chemicals-discovered-in-contaminated-soil/">chemicals</a> make modern life easier, they carry a hidden cost. PFAS are often called “forever chemicals” because they do not break down naturally in the environment. 



Once released, they linger in soil, water, and living organisms. Scientists have been studying their effects on human health for decades.



<h2 class="wp-block-heading" id="h-chemicals-and-the-male-brain">Chemicals and the male brain</h2>



One particular chemical, perfluorohexanoic acid (PFHxA), has recently gained attention. Many believed PFHxA, due to its shorter chemical chain, was safer than other PFAS. 



However, new research from the Del Monte Institute for Neuroscience at the <a href="https://www.rochester.edu/?gad_source=1&amp;gad_campaignid=22012609168&amp;gclid=Cj0KCQjw1JjDBhDjARIsABlM2StGMBIvmL07X0Z3q-t_9jIUIEPpx5WqGCxapBXIVnzuDwbDzEdilhUaAiDXEALw_wcB">University of Rochester</a> presents a different story.



In the latest study, scientists uncovered that early life <a href="https://www.earth.com/news/gut-bacteria-offer-new-hope-against-forever-chemicals/">exposure</a> to PFHxA may trigger anxiety-related behaviors and memory issues in male mice.



“Although these effects were mild, finding behavioral effects only in males was reminiscent of the many neurodevelopmental disorders that are male-biased,” said Ania Majewska, PhD, professor of Neuroscience and senior author of the study.



The researchers noted that males are more frequently diagnosed with disorders such as autism and ADHD. “This finding suggests that the male brain might be more vulnerable to environmental insults during neurodevelopment,” Majewska added.



<h2 class="wp-block-heading" id="h-chemical-exposure-and-brain-development">Chemical exposure and brain development </h2>



The research team exposed pregnant and nursing mice to PFHxA through mealworm treats. The chemical affected their offspring, particularly the brains of male mice.



The male offspring who received higher doses showed several <a href="https://www.earth.com/news/forever-chemicals-threaten-arctic-wildlife-and-human-health/">changes</a>. These included reduced activity, increased anxiety-like behavior, and memory problems. Interestingly, female mice exposed similarly showed no such changes.



“Finding that developmental exposure to PFHxA has long-term behavioral consequences in a mammalian model is concerning when considering short-chain PFAS are thought to be safer alternatives to the legacy PFAS that have been phased-out of production,” said Elizabeth Plunk, first author of the study.



<h2 class="wp-block-heading" id="h-long-term-effects-of-pfhxa-exposure">Long-term effects of PFHxA exposure</h2>



The team monitored the mice into adulthood. They discovered that male mice exposed to PFHxA retained behavioral changes well beyond their early life stages.



“This work points to the need for more research in short-chain PFAS. To our knowledge, PFHxA has not been evaluated for developmental neurobehavioral toxicity in a rodent model,” said Majewska.



“Future studies should evaluate the cellular and molecular <a href="https://www.earth.com/news/bacteria-strain-identified-that-can-eat-forever-chemicals/">effects</a> of PFHxA, including cell-type specific effects, in regions associated with motor, emotional/fear, and memory domains to elucidate mechanistic underpinnings.”



<h2 class="wp-block-heading" id="h-regulatory-actions-and-concerns">Regulatory actions and concerns</h2>



PFHxA’s shorter chain did not prevent it from persisting in water. The European Union restricted its use in 2024, following earlier restrictions on longer chain PFAS. 



Scientists remain concerned because PFHxA can easily spread through water systems, posing a threat to ecosystems and drinking water supplies.



In the United States, the Environmental Protection Agency recently set a national drinking water standard for PFAS. This action aims to reduce exposure for millions of people and prevent potential long-term health risks.



PFAS chemicals are found in food, water, animals, and humans. They resist stains, oil, and water but are linked to various health issues, including developmental problems in babies, certain cancers, immune system disruption, and hormonal imbalances. 



The ability of forever chemicals to build up in the body makes their health effects difficult to avoid over time.



<h2 class="wp-block-heading" id="h-further-research-is-needed">Further research is needed</h2>



The findings highlight the importance of examining chemicals considered “safe.” They reveal that even short-chain PFAS like PFHxA may pose hidden risks, especially to the developing brain.



According to the study authors, further research is needed. "These preliminary findings indicate that PFHxA exposure may cause long-lasting changes in many behavioral domains in a mammalian model, and more research is needed to expand these evaluations to other cognitive domains," they wrote.



The research received funding from the&nbsp;<a href="https://www.nih.gov/" target="_blank" rel="noreferrer noopener">National Institutes of Health</a>, the&nbsp;University of Rochester I<a href="https://www.urmc.rochester.edu/del-monte-neuroscience/idd-research-center" target="_blank" rel="noreferrer noopener">ntellectual and Developmental Disabilities Research Center</a>, and the&nbsp;University of Rochester <a href="https://www.urmc.rochester.edu/environmental-health-sciences" target="_blank" rel="noreferrer noopener">Environmental Health Sciences Center</a>.



The study is published in the <a href="https://onlinelibrary.wiley.com/doi/10.1111/ejn.70174" target="_blank" rel="noreferrer noopener">European Journal of Neuroscience</a>. 



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'Safe' forever chemicals may impair brain development

Everyday life is filled with conveniences that many people take...

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