Where you live may affect your dementia risk 
06-13-2025

Where you live may affect your dementia risk 

In one of the largest analyses of veteran medical records, experts have uncovered patterns that point to significant differences in dementia risk from one region of the United States to another.

The researchers used long-term data on more than one million older adults to highlight how location may link to memory-related health conditions.

The findings come from a study led by experts at the University of California, San Francisco. The team evaluated information spanning over two decades, offering detailed insights on where rates of this condition appear to rise more steeply.

Mapping the risk of dementia

The researchers compared several key regions to a Mid-Atlantic reference category, analyzing how frequently dementia appeared. There were substantial differences, even when accounting for health factors like cardiovascular disease.

According to the data, the Southeast region showed a 25% higher rate than the Mid-Atlantic.

The Northwest and Rocky Mountains both measured a 23% increase, followed by the South at 18% higher. The Southwest recorded a 13% rise, and the Northeast posted a 7% growth in dementia cases. 

Another striking aspect of the research was its inclusion of both rural and urban communities.

Many assumed that people in cities might get earlier diagnoses, while those in remote towns might face more barriers to care. The results suggest that the overall regional gap remains, regardless of population density.

Looking at the numbers

Experts have noted the importance of distinguishing dementia, which involves issues with thinking and daily function, from normal aging.

Over six million Americans are believed to be living with memory-related conditions, based on the latest estimates. 

“The study underscores the need to understand regional differences in dementia and the importance of region-specific prevention and intervention efforts,” said Dr. Kristin Yaffe, senior author of the research paper.

The experts plan to delve deeper into the reasons behind these geographic disparities, but this study offers a map of where new cases emerge more often.

Local factors may increase dementia risk

These findings encourage a careful look at local factors that might increase the risk. A closer examination could involve social conditions, such as education opportunities or consistent access to nutritious foods.

“Quality of education, early life conditions, and environmental exposures may be among those factors,” said Dr. Christina Dintica, lead author of the study.

Dr. Dintica plans to build on these observations in collaboration with other scientists to clarify what triggers or accelerates cognitive impairment in certain areas.

Strategies for early intervention

Some professionals suggest that regional differences might reflect variations in diagnostic practices.

Since many people rely on the Veterans Health Administration, there is a growing call for uniform screening tools that can identify problems in any setting. 

Many focus on cardiovascular health and other physical conditions that impact brain aging. Approaches that integrate preventive care, like good blood pressure control, might reduce the risk.

These strategies could be critical because early intervention has shown promise in lessening the impact of memory-related conditions.

Community organizations, local clinics, and broader public health campaigns can all work in tandem to educate people about signs of cognitive decline.

Targeted outreach to reduce dementia risk

Many families notice the toll that dementia takes on independence. When local healthcare resources lack specialized training, some conditions might slip through the cracks.

As a result, individuals could miss early support that might preserve their daily functioning. Regional studies, like this one, help put a spotlight on areas that might benefit most from targeted outreach.

Some policy experts point to the wide range of lifestyles across the country. The study offers a framework for pinpointing regions that could strengthen their health services.

States with large rural regions face the challenge of connecting residents to regular checkups. Others with diverse populations may need culturally tailored tools for spotting early cognitive warning signs.

Supporting healthier communities

Researchers see these results as a call to coordinate local and national resources. They hope improved data sharing will inform doctors, public officials, and community advocates. 

Updated screening efforts may yield earlier detection and help patients avoid complications. By understanding which locales show higher incidence, health professionals can adapt their strategies to serve those neighborhoods more effectively.

Some experts also predict new collaborations across state lines. Groups that have implemented successful brain health programs can show others how to replicate what works. 

Early education campaigns that encourage mental stimulation, balanced diets, and regular exercise may reduce the risk. These factors can support a healthier population and lessen the overall burden on healthcare systems.

Future research directions

This project is considered an important step for pinpointing the unique factors that drive memory concerns in different parts of the country. Research teams plan to examine multiple angles, from air quality to job markets, to see how they might influence older adults.

While some of these risk factors may overlap, clarifying their individual impact could improve healthcare planning.

The ultimate goal is to use this information to keep more people living independently in their communities.

Whether through improved diagnosis, better treatment methods, or programs that promote social connectedness, knowledge of risk patterns can shape everything from local clinics to statewide policies.

The study is published in the journal JAMA Neurology.

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